Strategically targeting myc in cancer

Author: dbqa

August undefined, 2024

Web7 Jun 2024 · Downregulating transcription of the oncogene c-MYC is a feasible strategy for cancer therapy. Selective small molecule that can target one particular G-quadruplex structure, and the selective ligand might serve as an excellent anticancer agent. ... Moreover, IZCZ-3 specifically downregulates c-MYC transcription in cancer cells. IZCZ-3 ...

A new approach to drugging a difficult cancer target

WebTopoisomerase (Topo) inhibitors have long been known as clinically effective drugs, while G-quadruplex (G4)-targeting compounds are emerging as a promising new strategy to target tumor cells and could support personalized treatment approaches in the near future. G-quadruplex (G4) is a secondary four-stranded DNA helical structure constituted of … Web11 Apr 2024 · The study investigates the role of nerve growth factor and its receptor, tropomyosin receptor kinase A, in triple-negative breast cancer and suggests that targeting TrkA may be a potential therapeutic strategy for this disease. jesus reaching hand out

Alternative approaches to target Myc for cancer treatment

Web4 Apr 2024 · purportedly B and plasma-cell exclusive protein [4], have developed on-target, off-tumour toxicities, displaying Parkinson’s-like symptoms attributed to expression in the basal ganglia [5]. These toxicities may even prove fatal, as was the case for a patient with metastatic colon cancer treated with a HER2-targeted CAR product. WebBackground: Small Cell Lung Cancer (SCLC) is a highly aggressive malignancy. MYC family oncogenes are amplified and overexpressed in 20% of SCLCs, showing that MYC oncogenes and MYC regulated genes are strong candidates as therapeutic targets for SCLC. c-MYC plays a fundamental role in cancer stem cell properties and malignant transformation. … WebNew anti-tumor strategies could take advantage of the direct relationship between glucose deprivation and polyamine metabolism impairment, leading to cell death, and its apparent dependence on n-myc. Combined therapies targeting glucose metabolism and polyamine synthesis could be effective in the treatment of n-myc-expressing tumors. inspireanation.org

Mission Possible: Advances in MYC Therapeutic Targeting in Cancer

Targeting advanced prostate cancer with STEAP1 chimeric …

WebHomogenizing Myc, either by limiting the number of upstream signaling inputs or by targeting the negative feedback regulation, may be a viable strategy in the future to target Myc-driven cancers. Finally, by identifying the time window where Myc is most important in determining cancer cell fate after chemotherapy, our results may help inform future … Web28 Jul 2010 · Strategies to target the MYC miRNA interplay in cancer. miRNA-based therapies could consist of either inhibition of oncogenic miRNAs using anti-miRNAs or of mimicking miRNAs with tumor suppressor functions. ... Kota et al. 101 set out to prove the principle of systemic delivery of a single MYC-repressed miRNA as a therapeutic strategy … inspireanation insuranceWebMCE 引用文献：PMID: 36950751 The clinical efficacy of personalized Cancer vaccines still needs to be improved due to their insufficient immune effect. The development of innovative adjuvants and lymph node-targeted delivery systems is the key to improving the clinical efficacy of personalized vaccines. However, there is still a lack of an adjuvant delivery … inspire amarillo facebook

"Web22 Jan 2024 · To identify small-molecule inhibitors targeting c-MYC for anticancer therapy, we designed a high-throughput screening (HTS) strategy utilizing cellular assays. The novel approach for the HTS was based on the detection of cellular c-MYC protein, with active molecules defined as those that specifically decreased c-MYC protein levels in cancer cells. " - Strategically targeting myc in cancer

Strategically targeting myc in cancer

Inducible expression of interleukin-12 augments the efficacy of ...

Web4 Jan 2024 · c-Myc is a transcription factor that is constitutively and aberrantly expressed in over 70% of human cancers. Its direct inhibition has been shown to trigger rapid tumor regression in mice with only mild and fully reversible side effects, suggesting this to be a viable therapeutic strategy. WebTargeting MYC. A major hurdle in clinical cancer therapeutics is that MYC oncogene family of transcription factors is an undruggable gene product, ie, not easily accessible for inhibition by small drug molecules. Therefore, other strategies are necessary. In general, direct or indirect inhibitors can be used to target the function of MYC.Direct strategies …

Did you know?

Web(A) Targeting the MYC/MAX interface by using 10058-F4, KJ-Pyr-9, or Omomyc inhibits binding to DNA and the MYC transcriptional pathway. (B) Indirect targeting of MYC … Web11 Apr 2024 · MB is a common childhood malignancy of the central nervous system, with significant morbidity and mortality. Among the four molecular subgroups, MYC-amplified …

Web11 Apr 2024 · Reprogrammed lipid metabolism is a hallmark of cancer that provides energy, materials, and signaling molecules for rapid cancer cell growth. Cancer cells acquire fatty acids primarily through de novo synthesis and uptake. Targeting altered lipid metabolic pathways is a promising anticancer strategy. However, their regulators have not been fully … Web11 Apr 2024 · Based on our findings, therapeutic effectiveness of such inhibitors against RAS-driven cancers warrants further investigation. In addition, direct inhibition of nucleolar Ncl, or its phospho-regulation downstream of RAS, could be another attractive strategy for targeting RAS-driven tumors. Materials and Methods Reagents and Tools table

Web1 Mar 2024 · The MYC proto-oncogene family encompasses three related transcription factors (MYC, MYCL, and MYCN), which are master regulators of cellular programs orchestrating multiple hallmarks of cancer, including proliferation, metabolism, invasiveness, and immune surveillance. WebSeveral recent findings indicate that MYC is a regulator of cancer genome and epigenome: MYC modulates expression of target genes in a site-specific manner, by recruiting chromatin remodeling co-factors at promoter regions, and at genome-wide level, by regulating the expression of several epigenetic modifiers that alter the entire chromatin structure.

Web14 Mar 2024 · One of the most common cancer-promoting genes, known as Myc, is also one of the most difficult to target with drugs. Scientists have long tried to develop drugs that block the Myc protein, but so far their efforts have not been successful.

WebBackground MYC oncogene is deregulated in 70% of all human cancers and is associated with multiple oncogenic functions including immunosuppression in the tumor microenvironment. The role of MYC in the immune microenvironment of neuroblastoma and melanoma is investigated and the effect of targeting Myc on immunogenicity of cancer … inspire and achieveWeb11 Apr 2024 · Targeting STAT3 function either by inducible genetic knockdown (KD) or with a clinically relevant small molecule inhibitor reduced tumorigenic attributes in MB cells, including survival, proliferation, anti-apoptosis, migration, stemness and … jesus read from the scrollsWeb23 Feb 2024 · Because strategies to directly target Myc have not been achieved thus far, essential targets involved in Myc deregulation have been exploited as new approaches to … inspire amplifier by dennis hadWeb23 Feb 2024 · Myc has a central role in almost every aspect of the oncogenic process, orchestrating proliferation, apoptosis, differentiation, and metabolism. Although Myc … jesus reading from the scroll in the templeWebMYC is a major driver of cancer cell growth and mediates a transcriptional program spanning cell growth, the cell cycle, metabolism, and cell survival. Many... DOAJ is a … inspire and aspire differenceWebChen, H., Liu, H., & Qing, G. (2024). Targeting oncogenic Myc as a strategy for cancer treatment. Signal Transduction and Targeted Therapy, 3(1). doi:10.1038/s41392 ... jesus reaching through waterWeb29 Mar 2016 · Europe PMC is an archive of life sciences journal literature. jesus read scriptures in the temple isaiah