Lxrα-cyp7a1
Web在肝脏，fxr上调小异二聚体伴侣（shp）表达，后者抑制胆汁酸合成的限速酶，胆固醇7α-羟化酶（cyp7a1）的表达。 FXR还诱导FGF19表达，从而激活肝FGF受体4（FGFR4）， … Web27 oct. 2024 · cyp7a1所诱导的胆汁酸代谢途径是胆固醇的主要代谢途径[2]。前期临床研究表明，消痰化瘀中药具有良好的调节血脂和治疗nafld作用[3]。为了进一步探讨其作用机制，本研究采用高脂饮食复制nafld大鼠模型，观察了消痰化瘀中药对模型大鼠lxrα和cyp7a1表达的 …
Lxrα-cyp7a1
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Web20 ian. 2015 · CSE/H 2 S deficiency decreases the expressions of LXRα and its target CYP7A1. LXRα downregulation leads to increased intestinal absorption of dietary cholesterol through the inhibition of NPC1L1. With a downregulated CYP7A1, liver cholesterols cannot be catabolized to bile acid, leading to accumulation of excess … WebThis study is the first to show that DXXK could alleviate lipid disorder and ameliorate atherosclerosis with downregulation of the PCSK9 in high-fat diet-fed ApoE–/– mice, suggesting that D XXK may be a potential novel therapeutic treatment and may support statin action in the treatment of atherosclerotic cardiovascular disease. Numerous risk …
WebDespite advances in healthcare, cardiovascular disease (CVD) remains the leading cause of death in the United States. Elevated levels of plasma cholesterol are highly predictive of CVD and stroke and are the principal driver of atherosclerosis.Unfortunately, current cholesterol lowering agents, such as statins, are not known to reverse atherosclerotic … Web26 apr. 2002 · Dietary cholesterol stimulates CYP7A1 transcription via activation of oxysterol receptor, LXR alpha, whereas bile acids repress transcription through FXR-mediated …
WebThe Cyp7a1 gene is also differentially regulated in mice compared to humans. In mice and rats, unlike humans, Cyp7a1 is upregulated by oxysterols upon CS feeding through LXRα activation [11, 13 ... Web11 dec. 2024 · The conversion of cholesterol into bile acids is regulated by LXRα-mediated stimulation of CYP7A1 transcription . LXRα is the predominant receptor in the liver, and is directly regulated by PPARγ [34, 35]. Therefore, this might explain the up-regulation of CYP7A1 after PPARγ upregulation resulting from the treatment with pioglitazone.
WebLXRα stimulates the transcription of mouse Cyp7a1, the rate-liming enzyme in the classical bile acid synthetic pathway. From: Vitamin D (Third Edition), 2011. ... (CYP7A1) is the …
Web27 nov. 2024 · Additionally, Cyp7a1 knockout mice expressing human Cyp7a1 exhibit different responses to altered diets than wild-type counterparts . This discrepancy is likely due to the lack of an LXRα binding sequence in the promoter region of the human gene . BA composition can, therefore, be experimentally manipulated highlighting the potential ... body contouring online trainingWeb6 oct. 2009 · The classical pathway begins with the rate-limiting 7-α hydroxylation of cholesterol by cholesterol 7-α hydroxylase (CYP7A1) and the 12-α hydroxylation of the intermediates by sterol 12-α hydroxylase ... The receptor LXRα has never been previously described in the human ovary , ... glastonbury theatreWebCompounds featuring a 1,2,4-oxadiazole core have been recently identified as a new chemotype of farnesoid X receptor (FXR) antagonists. With the aim to expand this class of compounds and to understand the building blocks necessary to maintain the antagonistic activity, we describe herein the synthesis, the pharmacological evaluation, and the in … body contouring philadelphiaWeb1 feb. 2004 · Figure 1. Stimulation of the human CYP7A1 gene promoter by WY 14,643 is abolished by the co‐expression of PPARα and LXRα in a ligand‐dependent manner. The … glastonbury themed partyWeb21 aug. 2013 · However, not all LXRα target genes were altered in miR-155 −/− livers, despite changes in LXRα expression (e.g. Cyp7a1 and Srebp1). We cannot exclude the possibility that these genes may be altered at other time points in the model and thus contribute to the observed phenotype. Furthermore, miRNAs are thought to be involved … body contouring outlineWeb10 ian. 2001 · The cholesterol 7alpha-hydroxylase gene (CYP7A1) plays an important role in regulation of bile acid biosynthesis and cholesterol homeostasis. Oxysterol receptor, … body contouring picsWebConclusion: Our results indicate that the hypocholesterolemic activity of cyanidin-3-O-β-glucoside was, at least in part, mediated by activating the potential LXRα-CYP7A1-bile … body contouring posters