Chromopyrrolic acid

WebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate ammonia-lyase (dichlorochromopyrrolate-forming). [1] [2] This enzyme catalyses the following chemical reaction 4 2-imino-3- (7-chloroindol-3-yl)propanoate + O 2 WebJan 23, 2006 · Chromopyrrolic acid is indicated by filled arrow head, and indole-3-pyruvic acid is indicated by blank arrow heads. Presumably, because of the coexistence of keto …

Targeted metagenomics: finding rare tryptophan dimer …

WebChromopyrrolic acid is a pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. It has a role as a bacterial … WebMay 20, 2024 · 多环特特拉姆酸大环内酰胺(polycyclic tetramate macrolactams，PTMs)是一类母核结构经PKS-NRPS杂合途径生物合成由特特拉姆酸(tetramic acid)结构和多环体系(常为2～3环)构成的内酰胺类化合物，具备抗肿瘤、抗细菌、抗真菌等生物活性[74].Hou等[75]前期通过培养条件优化的策略 ... cite my paper for free apa 7 https://koselig-uk.com

Dichlorochromopyrrolate synthase - Wikipedia

Webtion of tryptophan to the imine form of indole-3-pyruvic acid (IPA imine), and StaD then catalyzes the coupling of two molecules of IPA imine to yield chromopyrrolic acid (CPA). Finally, the key skeleton structure referred to as the indolocar-bazole core is constructed through the following two oxidation steps by StaP and StaC (2, 4) (Fig. 1B). WebApr 24, 2009 · Chromopyrrolic acid 11 is a shunt product and not a precursor to violacein (Balibar and Walsh, 2006, Sánchez et al., 2006a). A filtration-HPLC assay established that VioE, the next enzyme in the pathway, acts on an as yet uncharacterized intermediate produced by VioB to generate prodeoxyviolacein 19 (Balibar and Walsh, 2006). WebDec 29, 2004 · The following compounds were purified from S. albus harboring the plasmids mentioned in brackets: chromopyrrolic acid 1 (pCS014), K-252c or staurosporine aglycone 3 (pCS039), 11-chlorochromopyrrolic acid 7 (pCS018), 1-chloroarcyriaflavin 9 (pCS020), 9-chlorochromopyrrolic acid 21 (pCS049) and 3-chloroarcyriaflavin 23 (pCS037). diane leyre facebook

Staurosporine and Rebeccamycin Aglycones Are Assembled by the …

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Chromopyrrolic acid

Crystallographic trapping in the rebeccamycin biosynthetic ... - PNAS

WebJan 11, 2005 · The results suggest that indolocarbazole is constructed by oxidative decarboxylation of chromopyrrolic acid generated from two molecules of tryptophan by coupling and that the oxidation state at the C-7 position depends on the additional enzyme(s) encoded by the biosynthetic genes. Expand WebMay 13, 2015 · As suggested by our phylogenetic analysis of CPAS genes, identified in our survey of crude eDNA extracts, reductasporine (2) contains an unprecedented TD core structure: a pyrrolinium indolocarbazole core that is …

Chromopyrrolic acid

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WebIndole-3-pyruvic acid can be used: As a precursor for the synthesis of chromopyrrolic acid by a heme-containing enzyme.As a reactant in the Biginelli-like scaffold syntheses. Packaging. 1, 5 g in poly bottle. Linkage. α-Keto analogue … WebJan 23, 2006 · StaP on its own converts chromopyrrolic acid into three aglycone products, K252c, arcyriaflavin A, and 7-hydroxy-K252c; in the presence of StaC, K252c is the predominant product, while the ...

Web≥97% Synonym (s): 3- (3-Indolyl)-2-oxopropanoic acid, 3-Indolylpyruvic acid Empirical Formula (Hill Notation): C11H9NO3 CAS Number: 392-12-1 Molecular Weight: 203.19 Beilstein: 172966 EC Number: 206-874-1 … WebTwo complementary concise total syntheses of lycogarubin C ( 1) and lycogalic acid ( 2, aka chromopyrrolic acid) are detailed utilizing a 1,2,4,5-tetrazine → 1,2-diazine → pyrrole Diels−Alder strategy and enlisting acetylenic dienophiles. Supporting Information Full experimental details and compound characterizations.

WebSep 25, 2007 · The biosynthesis of rebeccamycin, an antitumor compound, involves the remarkable eight-electron oxidation of chlorinated chromopyrrolic acid. Although one rebeccamycin biosynthetic enzyme is capable of generating low levels of the eight-electron oxidation product on its own, a second protein, RebC, is required to accelerate product … WebMay 20, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; …

WebMay 1, 2015 · We provide the first experimental evidence for intermediates being involved in catalysis by RebD in generating the chromopyrrolic acid (CPA) scaffold of …

WebJul 10, 2007 · Staurosporine isolated from Streptomyces sp. TP-A0274 is a member of the family of indolocarbazole alkaloids that exhibit strong antitumor activity. A key step in … cite my references in apaWebApr 16, 2009 · Figure 1. Chromatogram showing baseline resolution of the 13 alcohols in the order listed in Table 1. Chromatographic conditions: 6 ft (∼180 cm)×2 mm ID glass … cite my source bibWebChromopyrrolic Acid. Chromopyrrolic acid (55) formation is catalyzed by the chromopyrrolic acid synthase ClaD. From: The Alkaloids: Chemistry and Biology, … cite my paper harvardWebSep 25, 2007 · The minor peaks indicate that, at low levels, chromopyrrolic acid spontaneously degrades under aerobic conditions at room temperature. This result … cite my page freeWebJan 1, 2014 · Although most P450s catalyze monooxygenation reactions, there are some exceptions. One example is P450 StaP, which is a key enzyme for forming the core structure of an anticancer agent, indolocarbazole, which catalyzes the intramolecular C–C bond formation in chromopyrrolic acid (CPA). diane light insuranceWebHere, we have coupled a chemical-biogeographic survey of chromopyrrolic acid synthase (CPAS) gene diversity with targeted eDNA library … diane lindsey californiaWebJan 3, 2024 · Indole pyruvic acid (IPA) is a versatile platform intermediate and building block for a number of high-value products in the pharmaceutical and food industries. It also has … diane l hallenbeck wells fargo albany ny