Btg2 t cell
WebAug 23, 2024 · Our results also indicate some apparently contradictory findings, such as the expression levels of genes for cell cycle arrest proteins, Chek2 and Btg2, were decreased 2.2- and 3.5-fold, respectively in FLT samples, contrary to what is expected for Chek2 when Myc is overexpressed based on what is observed in lymphoma cells . WebBTG2 can improve the radiosensitivity of breast cancer cells by affecting cell cycle distribution, enhancing radiation-induced apoptosis, and inhibiting DNA repair-related protein expression. TIS21 suppresses invadopodia formation as well as invasion activity along with F-actin remodeling.
Btg2 t cell
Did you know?
WebFunction [ edit] The BTG1 gene locus has been shown to be involved in a t (8;12) (q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. It is a member of a family of antiproliferative genes. BTG1 expression is maximal in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. WebMar 8, 2024 · B-cell translocation gene 2 ( BTG2 ), a member of the anti-proliferative BTG/TOB gene family, 9 maps within a chromosomal segment (1q32) 10 and contains …
WebSince the identification of B-cell translocation gene 1 (BTG1) and BTG2 as antiproliferation genes more than two decades ago, their protein products have been implicated in a variety of cellular processes including cell division, DNA repair, transcriptional regulation and messenger RNA stability. WebBTG2 INFORMATION. Proteini. Full gene name according to HGNC. BTG anti-proliferation factor 2. Gene namei. Official gene symbol, which is typically a short form of the gene name, according to HGNC. BTG2 (APRO1, MGC126063, MGC126064, PC3, TIS21) Protein classi. Assigned HPA protein class (es) for the encoded protein (s).
WebThe BTG2 expression is downregulated in many human cancers. It is an instantaneous early response gene and plays important roles in cell differentiation, proliferation, … WebApr 8, 2024 · The liquid biopsy includes the detection of circulating tumor cells (CTCs) and CTC clusters in blood, as well as the detection of, cell-free DNA (cfDNA)/circulating tumor DNA (ctDNA) and extracellular vesicles (EVs) in the patient's body fluid. Liquid biopsy has important roles in translational research. But its clinical utility is still under investigation. …
WebFor example, the BTG2-PRMT1 protein complex was found to antagonize the proliferation of pre-B cells to promote the development of B cells. 27,28 In a MO5 melanoma transplantation model, BTG2 was found to transiently regulate anti-tumor immunity by affecting the frequencies of granzyme B+ CD8+ T-cells and CD107a+ CD8+ T-cells in …
WebNov 18, 2014 · The BTG2 expression is downregulated in many human cancers. It is an instantaneous early response gene and plays important roles in cell differentiation, proliferation, DNA damage repair, and apoptosis in cancer cells. Moreover, BTG2 is regulated by many factors involving different signal pathways. bootstrap warning iconWebJun 27, 2016 · Btg2 was first isolated in screens designed to identify primary response genes induced by growth factors in PC12 cells or mitogenic agent in 3T3 cells 32,33. First, we determined the levels of ... hattie mae white bldg houston txhattie mae white hisdWebApr 3, 2024 · B-cell translocation gene 2 (BTG2, also called PC3/Tis21) was identified as an anti-proliferative protein regulated by p53 activation [ 14] and was initially described as an immediate early gene induced by growth factors and tumor promoters in PC12 and Swiss 3T3 cells [ 15, 16 ]. hattie maes in atlantaWebInterestingly, several signaling pathways were identified, including the presence of a T-cell receptor signaling signature in early B-cells of Btg1−/−; Btg2−/− mice showing upregulation of Cd3d ( Cd3delta) and Cd3g ( Cd3gamma) ( Online Supplementary Table S1 ). hattie mae hot chickenWebNov 10, 2024 · B-cell translocation gene 1 (BTG1) is a participant of the anti-proliferative (APRO) family proteins, which prevent cancer cell growth and stimulate cancer cell apoptosis [ 71]. Interestingly, the expression of BTG1 in gut intraepithelial lymphocytes is … bootstrap was developed byWebSep 1, 2024 · The mRNA expression level of BTG2 was lower in H460 cells compared with that in BEAS-2B normal lung epithelial cells. BTG2 expression was elevated upon IR exposure, in a dose-dependent but not a ... hattie mae wyatt